Inactivation of cardiolipin synthase triggers changes in mitochondrial morphology
نویسندگان
چکیده
منابع مشابه
Role of Cardiolipin in Mitochondrial Signaling Pathways
The phospholipid cardiolipin (CL) is an essential constituent of mitochondrial membranes and plays a role in many mitochondrial processes, including respiration and energy conversion. Pathological changes in CL amount or species composition can have deleterious consequences for mitochondrial function and trigger the production of reactive oxygen species. Signaling networks monitor mitochondrial...
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Phosphatidylglycerol (PG) and cardiolipin (CL) are two essential classes of phospholipid in plants and algae. Phosphatidylglycerophosphate synthase (PGPS) and cardiolipin synthase (CLS) involved in the biosynthesis of PG and CL belong to CDP-alcohol phosphotransferase and share overall amino acid sequence homology. However, it remains elusive whether PGPS and CLS are functionally distinct in vi...
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We present a novel platform for investigating the composition-specific interactions of proteins (or other biologically relevant molecules) with model membranes composed of compositionally distinct domains. We focus on the interaction between a mitochondrial-specific lipid, cardiolipin (CL), and a peripheral membrane protein, cytochrome c (cyt c). We engineer vesicles with compositions such that...
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ATP synthases are remarkable proteins that regenerate the molecular fuel for cellular processes in all domains of life (1). Embedded into the inner membranes of mitochondria, chloroplasts, and bacteria, FoF1-ATP synthase produces most of the cellular ATP, using ADP and inorganic phosphate as inputs (Fig. 1A). This thermodynamically unfavorable reaction is powered by a proton electrochemical gra...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 2017
ISSN: 0014-5793,1873-3468
DOI: 10.1002/1873-3468.12948